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Urea

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Medicinal Urea





 


Pharmacological ActionIt can dissolve protein, increase protein hydration, improve the skin penetrability, and has the function of anti-bacteria, anti-itch and dehydration.

Application: It is extensively used in ointments and injections, and indicated for treatment of ichthyosis, rhagades manus et pedes, palmoplantar keratoderma, pityriasis rubra pilaris, eczema rhagadiforme, senile pruritus and hemangiomas.

The Main Quality Specification: A special purified process was developed and applied to manufacture medicinal urea in our company. The urea produced by our company is with high purity, low impurity content and stable quality. The content of urea is not less than 99.7%. And the content of main impurity, biuret, is not more than 0.1%. And the quality specification in detail see Table 4.

 

Table 4 The Main Quality Specification of Medicinal Urea

Test items

The quality of product

Appearance

It is a colourless prismatic crystal or white crystalline powder, almost odourless, salty and cold. A small quantity of ammonia will be given off after it is stored for a long time. The aqueous solution of the product is neutral.

Melting Point

132-135

Identification

Identification 1

Positive reaction

Identification 2

Positive reaction

IR Spectrum

The IR spectrum of sample is consistent with the standard substanceNo. 210 in Spectrogram Collection

Chloride

0.0003%

Sulphate

0.001%

Insoluble Substances in Ethanol

2mg

Residue on Ignition

0.1%

Heavy Metal

20ppm

Biruet

0.1%

Ferrum

0.001%

Free Ammonia

0.005%

Content of urea

99.7%

 

 

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